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Exosomes are the natural by-product of cells. They are often described as microscopic bubbles or (in the scientific world) as nano extracellular vesicles. It’s now recognised that these tiny molecules have an enormous role to play in skin and hair rejuvenation. Although they’re not cells—which means they don’t have the ability to replicate, they are however important for tissue healing, regeneration and repair.
Exosomes contain biomolecules including proteins, growth factors, lipids and nucleic acids such as messenger-RNA, (mRNA) and micro-RNA (miRNA). They act as messengers between cells.
Think of them as little envelopes of regeneration that get sent from cell to cell.
Exosomes can increase:
PLATELET RICH PLASMA (PRP) OR VAMPIRE FACIAL
WHAT IS IT?: This is an effective skin rejuvenation technique that has received wide media coverage with celebrities undergoing the procedure for a youthful complexion. When combined with microneedling it’s commonly referred to as the ‘vampire facial’ because it involves drawing blood and then coating the skin with it.
THE PROCESS: The process involves drawing blood from the patient's arm,
then a centrifuge spins the blood at high speeds to separate the plasma and platelets from the rest of the blood (red and white blood cells) which is not needed and discarded. The PRP is highly concentrated, full of nutrients and growth factor proteins which are known to assist wound healing.
Then with a microneedling technique or post CO2 laser, the PRP is massaged into the skin, the micro-channels allow the PRP to be delivered into the deep layers for rejuvenation.
The PRP is donor dependent, and not sourced from the youngest purest regenerative possibilities and results may vary depending on several factos like: patien's health, amount of growth factos and cells, technique of extraction, medications that the patient is taking at the time of the treatment, etc.
The good news is skin rejuvenation therapy is evolving.
The next level up from PRP is microneedling with exosomes.
EXOSOMES
Exosomes are obtained from healthy human donors, extracted from umbilical cord and placenta stem cells which then are stimulated to be converted into mesenchymal cells and produce the exosomes.
We don't need blood samples because we already have the exact amount in sterile vials ready to be applied.
Exosomes do not change the DNA of a cell; they contain the no human DNA. They are not gene therapy.
Exosomes promote skin cell proliferation -in vitro - by up to 80% in a dose dependent manner. With 4 billion exosomes it had a 36.1% increase, and with 8 billion an 84.0% increase, compared against positive control (1% GS).
Exosomes increases the elastin amount of human dermal fibroblasts up to 300% in vitro.
After delivery of Exosomes into fibroblasts, neocollagenesis can increase up to 6 folds.
Human skin cells easily uptake Exosomes which means that stem cell-derived exosomes can message skin cells to “Do Something”.
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